Article
Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis.
Journal of medical genetics - 1 Nov 2000
Hansford J R, Mulligan L M
Abstract excerpt
Multiple endocrine neoplasia type 2 (MEN 2) is an inherited cancer syndrome characterised by medullary thyroid carcinoma (MTC), with or without phaeochromocytoma and hyperparathyroidism. MEN 2 is unusual among cancer syndromes as it is caused by activation of a cellular oncogene, RET. Germline mutations in the gene encoding the RET receptor tyrosine kinase are found in the vast majority of MEN 2 patients and...
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