Article
RET signaling in endocrine tumors: delving deeper into molecular mechanisms.
Endocrine pathology - 1 Jan 2007
Lai Andrea Z, Gujral Taranjit S, Mulligan Lois M
Abstract excerpt
The rearranged during transfection (RET) proto-oncogene encodes a receptor tyrosine kinase that is implicated in the development of endocrine tumors of the thyroid and adrenal glands. In humans, activating RET mutations are found in the inherited cancer syndrome multiple endocrine neoplasia 2 and in sporadic medullary and papillary thyroid carcinomas. The specific type and location of RET mutations are strongly...
Topics
- Animals
- Endocrine Gland Neoplasms
- Humans
- Models, Molecular
- Multiple Endocrine Neoplasia Type 2a
- Mutation
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-ret
- Signal Transduction