RET proto oncogene mutation detection and medullary thyroid carcinoma prevention.

doi:10.7314/apjcp.2015.16.6.2107

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Article

RET proto oncogene mutation detection and medullary thyroid carcinoma prevention.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015

Yeganeh Marjan Zarif, Sheikholeslami Sara, Hedayati Mehdi

Abstract excerpt

Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is autosomal dominantly and gain of function mutations in the RET proto-oncogene are well known to contribute to its development. MTC occurs as hereditary (25%) and sporadic (75%)...

Topics

Carcinoma, Neuroendocrine
Early Detection of Cancer
Humans
Mutation
Proto-Oncogene Mas
Proto-Oncogene Proteins c-ret
Thyroid Neoplasms

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PMID: 25824727
DOI: 10.7314/apjcp.2015.16.6.2107

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