Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer.

Expert review of anticancer therapy - 1 Apr 2008

Lodish Maya B, Stratakis Constantine A

Abstract excerpt

Hereditary medullary thyroid carcinoma (MTC) is caused by specific autosomal dominant gain-of-function mutations in the RET proto-oncogene. Genotype-phenotype correlations exist that help predict the presence of other associated endocrine neoplasms as well as the timing of thyroid cancer development. MTC represents a promising model for targeted cancer therapy, as the oncogenic event responsible for initiating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Medullary
Share to Multiple Endocrine Neoplasia Type 2a
Share to Multiple Endocrine Neoplasia Type 2b

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-ret

Share to Receptor Protein-Tyrosine Kinases

Share to Thyroid Neoplasms

Share to Thyroidectomy

Source

Open in PubMed Open full text

Identifiers

PMID: 18402529
DOI: 10.1586/14737140.8.4.625
PMCID: PMC2670186

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer.PMID 18402529Read ↗

RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma.Semantic proximity Read ↗

Molecular advances in medullary thyroid cancer diagnostics.Semantic proximity Read ↗

RET proto oncogene mutation detection and medullary thyroid carcinoma prevention.Semantic proximity Read ↗

RET as a Diagnostic and Therapeutic Target in Sporadic and Hereditary Endocrine TumorsSemantic proximity Read ↗

Molecular mechanisms of medullary thyroid carcinoma: current approaches in diagnosis and treatment.Semantic proximity Read ↗

Update on Multiple Endocrine Neoplasia Type 2: Focus on Medullary Thyroid CarcinomaSemantic proximity Read ↗

Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC.Semantic proximity Read ↗

Molecular Mechanisms of RET Activation in Human CancerSemantic proximity Read ↗

RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors.Semantic proximity Read ↗

Multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma: an update.Semantic proximity Read ↗

RET tyrosine kinase signaling in development and cancer.Semantic proximity Read ↗

Advances in the management of MEN2: from improved surgical and medical treatment to novel kinase inhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.