Article
RET tyrosine kinase signaling in development and cancer.
Cytokine & growth factor reviews - 1 Jan 2000
Arighi Elena, Borrello Maria Grazia, Sariola Hannu
Abstract excerpt
The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are associated with human cancer. Gene rearrangements juxtaposing the tyrosine kinase domain to heterologous gene partners have been found in sporadic papillary carcinomas of the thyroid (PTC). These rearrangements generate chimeric RET/PTC...
Topics
- Hirschsprung Disease
- Humans
- Mutation
- Neoplasms
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ret
- Receptor Protein-Tyrosine Kinases
- Signal Transduction
- Thyroid Neoplasms