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Article

Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli.

Pain - 5 Dec 2006

Diatchenko Luda, Nackley Andrea G, Slade Gary D, Bhalang Kanokporn, Belfer Inna, Max Mitchell B, Goldman David, Maixner William

Abstract excerpt

Variations in the gene encoding catechol-O-methyltransferase (COMT) are linked to individual differences in pain sensitivity. A single nucleotide polymorphism (SNP) in codon 158 (val(158)met), which affects COMT protein stability, has been associated with the human experience of pain. We recently demonstrated that three common COMT haplotypes, which affect the efficiency of COMT translation, are strongly...

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Source

Identifiers

PMID: 16837133
DOI: 10.1016/j.pain.2006.05.024

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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