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Article

COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor.

Science (New York, N.Y.) - 21 Feb 2003

Zubieta Jon-Kar, Heitzeg Mary M, Smith Yolanda R, Bueller Joshua A, Xu Ke, Xu Yanjun, Koeppe Robert A, Stohler Christian S, Goldman David

Abstract excerpt

Responses to pain and other stressors are regulated by interactions between multiple brain areas and neurochemical systems. We examined the influence of a common functional genetic polymorphism affecting the metabolism of catecholamines on the modulation of responses to sustained pain in humans. Individuals homozygous for the met158 allele of the catechol-O-methyltransferase (COMT) polymorphism (val158met) showed...

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Source

Identifiers

PMID: 12595695
DOI: 10.1126/science.1078546

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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