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Article

Genetic variation in catechol-O-methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects.

The journal of gene medicine - 1 Nov 2021

Korczeniewska Olga A, Kuo Fengshen, Huang Ching-Yu, Nasri-Heir Cibele, Khan Junad, Benoliel Rafael, Hirschberg Craig, Eliav Eli, Diehl Scott R

Abstract excerpt

BACKGROUND: Genetic variation in the catechol-O-methyltransferase (COMT) gene is associated with sensitivity to both acute experimental pain and chronic pain conditions. Four single nucleotide polymorphisms (SNPs) have traditionally been used to infer three common haplotypes designated as low, average and high pain sensitivity and are reported to affect both COMT enzymatic activity and pain sensitivity. One...

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Identifiers

PMID: 34156736
DOI: 10.1002/jgm.3374
PMCID: PMC9926975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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