Article
The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.
PloS one - 1 Jan 2011
Loggia Marco L, Jensen Karin, Gollub Randy L, Wasan Ajay D, Edwards Robert R, Kong Jian
Abstract excerpt
Despite the explosion of interest in the genetic underpinnings of individual differences in pain sensitivity, conflicting findings have emerged for most of the identified "pain genes". Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT), as its substantial association to pain sensitivity has been reported in various studies, but rejected in several others. In line...
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