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Article

Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model - An Explorative Study.

Basic & clinical pharmacology & toxicology - 1 Oct 2016

Nielsen Lecia Møller, Olesen Anne Estrup, Sato Hiroe, Christrup Lona Louring, Drewes Asbjørn Mohr

Abstract excerpt

The genetic influence on sensitivity to noxious stimuli (pain sensitivity) remains controversial and needs further investigation. In the present study, the possible influence of polymorphisms in three opioid receptor (OPRM, OPRD and OPRK) genes and the catechol-O-methyltransferase (COMT) gene on pain sensitivity in healthy participants was investigated. Catechol-O-methyltransferase has an indirect effect on the...

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Catechol O-Methyltransferase
Denmark
Ligands
Pain Measurement
Pain Threshold

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Opioid, delta

Receptors, Opioid, kappa

Receptors, Opioid, mu

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Identifiers

PMID: 27061127
DOI: 10.1111/bcpt.12601

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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