Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in the COMT gene: implications for pain perception and pain treatment.

Pharmacogenomics - 1 Apr 2009

Andersen Sonja, Skorpen Frank

Abstract excerpt

Catechol-O-methyltransferase (COMT) is an enzyme that inactivates biologically-active catechols, including the important neurotransmitters dopamine, noradrenaline and adrenaline. These neurotransmitters are involved in numerous physiological processes, including modulation of pain. Genetic variation in the COMT gene has been implicated in variable response to various experimental painful stimuli, variable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to Catechol O-Methyltransferase
Share to COMT gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Pain Mechanisms and Treatments

Share to Pain Threshold

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 19374521
DOI: 10.2217/pgs.09.13

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in the COMT gene: implications for pain perception and pain treatment.PMID 19374521Read ↗

COMT genetic variants and pain.Semantic proximity Read ↗

COMT gene locus: new functional variants.Semantic proximity Read ↗

Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis.Semantic proximity Read ↗

Genetic basis for individual variations in pain perception and the development of a chronic pain conditionSemantic proximity Read ↗

Pain modality- and sex-specific effects of COMT genetic functional variants.Semantic proximity Read ↗

Are catechol-O-methyltransferase gene polymorphisms genetic markers for pain sensitivity after all? - A review and meta-analysis.Semantic proximity Read ↗

The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.Semantic proximity Read ↗

Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.Semantic proximity Read ↗

Modification of COMT-dependent pain sensitivity by psychological stress and sex.Semantic proximity Read ↗

Effect of catechol-o-methyltransferase-gene (COMT) variants on experimental and acute postoperative pain in 1,000 women undergoing surgery for breast cancer.Semantic proximity Read ↗

Genetic Influences of OPRM1, OPRD1 and COMT on Morphine Analgesia in a Multi-Modal, Multi-Tissue Human Experimental Pain Model.Semantic proximity Read ↗

Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.