Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism in Conditioned Pain Modulation in Women with Migraine.

International journal of molecular sciences - 4 Jun 2026

Cigarán-Méndez Margarita, de-la-Llave-Rincón Ana I, Pacho-Hernández Juan C, Tejera-Alonso Angela, Gómez-Calero Cristina, Fernández-de-Las-Peñas César, Arendt-Nielsen Lars, Ambite-Quesada Silvia

Abstract excerpt

The role of the catechol-O-methyltransferase (COMT) Val158Met rs4680 polymorphism in altered pain processing in headaches is controversial. The aim of this study was to investigate the influence of the Val158Met rs4680 polymorphism in conditioned pain modulation (CPM) in women with migraine. A case-control study including 70 women with chronic migraine, 70 with episodic migraine and 70 pain-free women was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles
Share to Case-Control Studies
Share to Catechol O-Methyltransferase
Share to Gene Frequency
Share to Migraine Disorders
Share to Pain
Share to Pain Threshold
Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42278631
DOI: 10.3390/ijms27115107
PMCID: PMC13257405

Genes

CPM
COMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism in Conditioned Pain Modulation in Women with Migraine.PMID 42278631Read ↗

Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type HeadacheSemantic proximity Read ↗

The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.Semantic proximity Read ↗

Are catechol-O-methyltransferase gene polymorphisms genetic markers for pain sensitivity after all? - A review and meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome.Semantic proximity Read ↗

Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli.Semantic proximity Read ↗

Genetic variation in catechol-O-methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects.Semantic proximity Read ↗

Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in children with chronic tension-type headache.Semantic proximity Read ↗

Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia.Semantic proximity Read ↗

Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis.Semantic proximity Read ↗

The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation.Semantic proximity Read ↗

No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain.Semantic proximity Read ↗

Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.