Article
No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain.
Annals of the rheumatic diseases - 1 Nov 2010
Nicholl Barbara I, Holliday Kate L, Macfarlane Gary J, Thomson Wendy, Davies Kelly A, O'Neill Terence W, Bartfai Gyorgy, Boonen Steven, Casanueva Felipe, Finn Joseph D, Forti Gianni, Giwercman Aleksander, Huhtaniemi Ilpo T, Kula Krzysztof, Punab Margus, Silman Alan J, Vanderschueren Dirk, Wu Frederick C W, McBeth John
Abstract excerpt
OBJECTIVES: The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. METHODS: Cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The...
Topics
- Case-Control Studies
- Catechol O-Methyltransferase
- Chronic Disease
- Female
- Fibromyalgia
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes