Article
Pain modality- and sex-specific effects of COMT genetic functional variants.
Pain - 1 Aug 2013
Belfer Inna, Segall Samantha K, Lariviere William R, Smith Shad B, Dai Feng, Slade Gary D, Rashid Naim U, Mogil Jeffrey S, Campbell Claudia M, Edwards Robert R, Liu Qian, Bair Eric, Maixner William, Diatchenko Luda
Abstract excerpt
The enzyme catechol-O-methyltransferase (COMT) metabolizes catecholamine neurotransmitters involved in a number of physiological functions, including pain perception. Both human and mouse COMT genes possess functional polymorphisms contributing to interindividual variability in pain phenotypes such as sensitivity to noxious stimuli, severity of clinical pain, and response to pain treatment. In this study, we...
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