Article
Investigating CFTR and KCa3.1 Protein/Protein Interactions.
PloS one - 1 Jan 2016
Klein Hélène, Abu-Arish Asmahan, Trinh Nguyen Thu Ngan, Luo Yishan, Wiseman Paul W, Hanrahan John W, Brochiero Emmanuelle, Sauvé Rémy
Abstract excerpt
In epithelia, Cl- channels play a prominent role in fluid and electrolyte transport. Of particular importance is the cAMP-dependent cystic fibrosis transmembrane conductance regulator Cl- channel (CFTR) with mutations of the CFTR encoding gene causing cystic fibrosis. The bulk transepithelial transport of Cl- ions and electrolytes needs however to be coupled to an increase in K+ conductance in order to recycle K+...
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