Article
Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.
The Journal of biological chemistry - 28 Dec 2007
Broere Nellie, Hillesheim Jutta, Tuo Biguang, Jorna Huub, Houtsmuller Adriaan B, Shenolikar Shirish, Weinman Edward J, Donowitz Mark, Seidler Ursula, de Jonge Hugo R, Hogema Boris M
Abstract excerpt
Binding of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel to the Na(+)/H(+) exchanger 3 regulatory factor 1 (NHERF-1) and NHERF-2 scaffolding proteins has been shown to affect its localization and activation. We have for the first time studied the physiological role of these proteins in CFTR regulation in native tissue by determining CFTR-dependent chloride current in NHERF-1- and...
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