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Article

The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2017

Bertrand Carol A, Mitra Shalini, Mishra Sanjay K, Wang Xiaohui, Zhao Yu, Pilewski Joseph M, Madden Dean R, Frizzell Raymond A

Abstract excerpt

Several members of the SLC26A family of anion transporters associate with CFTR, forming complexes in which CFTR and SLC26A functions are reciprocally regulated. These associations are thought to be facilitated by PDZ scaffolding interactions. CFTR has been shown to be positively regulated by NHERF-1, and negatively regulated by CAL in airway epithelia. However, it is unclear which PDZ-domain protein(s) interact...

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Source

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Identifiers

PMID: 28360110
DOI: 10.1152/ajplung.00178.2016
PMCID: PMC5495941

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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