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Article

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.

Journal of cell science - 15 May 2009

Horikoshi Yosuke, Suzuki Atsushi, Yamanaka Tomoyuki, Sasaki Kazunori, Mizuno Keiko, Sawada Hajime, Yonemura Shigenobu, Ohno Shigeo

Abstract excerpt

The evolutionarily conserved polarity proteins PAR-3, atypical protein kinase C (aPKC) and PAR-6 critically regulate the apical membrane development required for epithelial organ development. However, the molecular mechanisms underlying their roles remain to be clarified. We demonstrate that PAR-3 knockdown in MDCK cells retards apical protein delivery to the plasma membrane, and eventually leads to mislocalized...

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Identifiers

PMID: 19401335
DOI: 10.1242/jcs.043174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.PMID 19401335Read ↗

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