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Article

Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.

The Journal of biological chemistry - 17 Jul 2009

Lamprecht Georg, Hsieh Chih-Jen, Lissner Simone, Nold Lilia, Heil Andreas, Gaco Veronika, Schäfer Julia, Turner Jerrold R, Gregor Michael

Abstract excerpt

The Na/H exchanger 3 (NHE3) and the Cl/HCO(3) exchanger down-regulated in adenoma (DRA) together facilitate intestinal electroneutral NaCl absorption. Elevated Ca(2+)(i) inhibits NHE3 through mechanisms involving the PDZ domain proteins NHE3 kinase A regulatory protein (E3KARP) or PDZ kidney 1 (P...

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Identifiers

PMID: 19447883
DOI: 10.1074/jbc.M109.004127
PMCID: PMC2740598

Genes

PDZK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19447883-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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