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Article

A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice.

Nature genetics - 1 Aug 2006

To Minh D, Perez-Losada Jesus, Mao Jian-Hua, Hsu Jeff, Jacks Tyler, Balmain Allan

Abstract excerpt

Pulmonary adenoma susceptibility 1 (Pas1) is the major mouse lung cancer susceptibility locus on chromosome 6 (ref. 1). Kras2 is a common target of somatic mutation in chemically induced mouse lung tumors and is a candidate Pas1 gene. M. spretus mice (SPRET/Ei) carry a Pas1 resistance haplotype for chemically induced lung tumors. We demonstrate that the SPRET/Ei Pas1 allele is switched from resistance to...

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Identifiers

PMID: 16823377
DOI: 10.1038/ng1836
PMCID: PMC4461000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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