Article
Cis-acting genomic elements of the Pas1 locus control Kras mutability in lung tumors.
Oncogene - 25 Sept 2008
Manenti G, Trincucci G, Pettinicchio A, Amendola E, Scarfò M, Dragani T A
Abstract excerpt
The Pas1 locus is the major tumor modifier of lung tumorigenesis in mouse inbred strains. Of six genes contained in a conserved haplotype, three (Casc1, Kras and Ifltd1) have been proposed as Pas1 candidates, but mechanistic evidence is sparse. Herein, we examined urethane-induced lung tumorigene...
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