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Article

Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias.

Carcinogenesis - 1 May 2008

Kohno Takashi, Kunitoh Hideo, Suzuki Kenji, Yamamoto Seiichiro, Kuchiba Aya, Matsuno Yoshihiro, Yanagitani Noriko, Yokota Jun

Abstract excerpt

The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC). In this study, genotype distributions for 10 polymorphisms in the human counterparts for three mouse candidate Pas1 genes, KRAS, CASC1/LAS1 and LRMP, were examined in a hospital-based case-control study consisting of 364 lung ADC...

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Source

Identifiers

PMID: 18299280
DOI: 10.1093/carcin/bgn048

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias.PMID 18299280Read ↗

Localization of a human lung adenocarcinoma susceptibility locus, possibly syntenic to the mouse Pas1 locus, in the vicinity of the D12S1034 locus on chromosome 12p11.2-p12.1.Semantic proximity Read ↗

Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.Semantic proximity Read ↗

Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas.Semantic proximity Read ↗

Mouse pulmonary adenoma susceptibility 1 locus is an expression QTL modulating Kras-4A.Semantic proximity Read ↗

Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma.Semantic proximity Read ↗

Predisposition to lung tumorigenesis.Semantic proximity Read ↗

A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients.Semantic proximity Read ↗

Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines.Semantic proximity Read ↗

Cis-acting genomic elements of the Pas1 locus control Kras mutability in lung tumors.Semantic proximity Read ↗

A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice.Semantic proximity Read ↗

Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.Semantic proximity Read ↗

The Kras2 oncogene and mouse lung carcinogenesis.Semantic proximity Read ↗

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