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Article

Efficient platelet delta-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa.

International journal of molecular medicine - 1 Aug 2006

Gobbi Giuliana, Sponzilli Ivonne, Mirandola Prisco, Tazzari Pier Luigi, Caimi Luigi, Cacchioli Antonio, Matteucci Alessandro, Giuliani Piccari Gabriella, Cocco Lucio, Vitale Marco

Abstract excerpt

Intracellular Ca2+ elevation generates a cascade of events that leads to platelet activation and degranulation. The GPIIbIIIa-ligand molecular complex plays a central role in several aspects of platelet activation. Taking advantage of the flow cytometric simultaneous analysis of surface GPIIbIIIa expression and intracellular serotonin content, we demonstrate here that the functional inhibition of GPIIbIIIa...

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PMID: 16820939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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