Article

RIP2 inhibits DOCK8-mediated platelet dense granule release and alleviates experimental myocardial infarction

2025-04-21

Abstract excerpt

<h4>Objective</h4> Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity downstream of pattern recognition receptors (PRRs). Platelets express RIP2, while its role in platelet activation, thrombosis, and myocardial infarction (MI) is unknown. <h4>Approach and Results</h4> Here we show that RIP2 deficiency enhances platelet dense granule secretion in response to GPIb a...

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Literature Corpus work: 14d306c5-8926-5f22-8a41-5ae6c7f3910b
DOI: 10.1101/2025.04.19.649674

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