Article

Novel regulators identified by quantitative phosphoproteomics analysis during ticagrelor-induced inhibition of platelet

2024-06-01

Abstract excerpt

<h4>Purpose: </h4> To study the antiplatelet mechanisms of ticagrelor. Experimental design: Platelets underwent activation with 20 μM ADP for 30 seconds followed by inhibition with 2 nM ticagrelor for another 30 seconds. Mass-spectrometry-based phosphoproteomic technique was applied to obtain phosphorylation spectra in platelets. <h4>Results:</h4> We successfully quantified 2285 phosphopeptides with high confidenc...

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Literature Corpus work: ac27dc99-f89f-5a1e-8b10-7cca15577651
DOI: 10.22541/au.171725432.22499032/v1

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