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Article

Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells.

The EMBO journal - 4 Aug 2004

Knop Markus, Aareskjold Elin, Bode Günther, Gerke Volker

Abstract excerpt

von-Willebrand factor (vWF) and tissue-type plasminogen activator (tPA) are products of endothelial cells acutely released into the vasculature following cell activation. Both factors are secreted after intraendothelial Ca2+ mobilization, but exhibit opposing physiological effects with vWF inducing coagulation and tPA triggering fibrinolysis. To identify components that could regulate differentially the release...

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Identifiers

PMID: 15257287
DOI: 10.1038/sj.emboj.7600319
PMCID: PMC514934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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