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Article

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.

Blood - 12 Aug 2010

Ren Qiansheng, Wimmer Christian, Chicka Michael C, Ye Shaojing, Ren Yi, Hughson Frederick M, Whiteheart Sidney W

Abstract excerpt

Activation-dependent platelet granule release is mediated by integral membrane proteins called soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs) and their regulators; however, the mechanisms for this process are ill-defined. To further characterize platelet secretion, we analyzed the function of platelets from Unc13d(Jinx) mice. Platelets from these animals lack the putative...

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Identifiers

PMID: 20435885
DOI: 10.1182/blood-2010-02-270934
PMCID: PMC2924225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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