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Article

Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets.

The Journal of biological chemistry - 12 Mar 2004

Shirakawa Ryutaro, Higashi Tomohito, Tabuchi Arata, Yoshioka Akira, Nishioka Hiroaki, Fukuda Mitsunori, Kita Toru, Horiuchi Hisanori

Abstract excerpt

Platelets store self-agonists such as ADP and serotonin in dense core granules. Although exocytosis of these granules is crucial for hemostasis and thrombosis, the underlying mechanism is not fully understood. Here, we show that incubation of permeabilized platelets with unprenylated active mutan...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanosine 5'-O-(3-Thiotriphosphate)

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Source

Identifiers

PMID: 14699162
DOI: 10.1074/jbc.M309426200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14699162-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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