Article
CD44 sensitivity of platelet activation, membrane scrambling and adhesion under high arterial shear rates.
Thrombosis and haemostasis - 1 Jan 2016
Liu Guilai, Liu Guoxing, Alzoubi Kousi, Chatterjee Madhumita, Walker Britta, Münzer Patrick, Luo Dong, Umbach Anja T, Elvira Bernat, Chen Hong, Voelkl Jakob, Föller Michael, Mak Tak W, Borst Oliver, Gawaz Meinrad, Lang Florian
Abstract excerpt
CD44 is required for signalling of macrophage migration inhibitory factor (MIF), an anti-apoptotic pro-inflammatory cytokine. MIF is expressed and released from blood platelets, key players in the orchestration of occlusive vascular disease. Nothing is known about a role of CD44 in the regulation of platelet function. The present study thus explored whether CD44 modifies degranulation (P-selectin exposure),...
Topics
- Animals
- Apoptosis
- Blood Coagulation
- Blood Platelets
- Calcium Channels
- Calcium Signaling
- Caspase 3
- Cell Degranulation
- Cell Membrane
- Chlorides