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Article

Evidence for a granule targeting sequence within platelet factor 4.

The Journal of biological chemistry - 26 Aug 2005

El Golli Nargès, Issertial Odile, Rosa Jean-Philippe, Briquet-Laugier Véronique

Abstract excerpt

Platelets achieve bleeding arrest at sites of vascular injury via secretion of secretory proteins from their storage granules, termed alpha-granules. We have recently analyzed granule targeting of platelet factor 4 (PF4), a secretory alpha-granule chemokine, and demonstrated that PF4 alpha-granule storage relied upon determinants within PF4 mature sequence. To define these determinants, PF4 mutants fused to the...

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PMID: 15964840
DOI: 10.1074/jbc.M503847200

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