Direct DNA sequencing of the rat neu oncogene transmembrane domain reveals no mutation in urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-methyl-N-nitrosourea.

doi:10.1093/carcin/12.10.1975

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Direct DNA sequencing of the rat neu oncogene transmembrane domain reveals no mutation in urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-methyl-N-nitrosourea.

Carcinogenesis - 1 Oct 1991

Masui T, Mann A M, Macatee T L, Garland E M, Okamura T, Smith R A, Cohen S M

Abstract excerpt

Epidermal growth factor (EGF) and EGF-related growth factors are present in the urine, and EGF has been identified as a urinary component that enhances urinary bladder tumor formation in rats. Neu oncogene encodes a cell surface receptor similar to the EGF receptor and is known to be activated by...

Topics

Amino Acid Sequence
Animals
Base Sequence
Butylhydroxybutylnitrosamine
DNA, Neoplasm
FANFT
Male
Membranes
Methylnitrosourea
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogenes

Polymerase Chain Reaction

Proto-Oncogene Proteins

Rats

Rats, Inbred F344

Receptor, ErbB-2

Saccharin

Source

Open in PubMed

Identifiers

PMID: 1682063
DOI: 10.1093/carcin/12.10.1975

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1682063-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Direct DNA sequencing of the rat neu oncogene transmembrane domain reveals no mutation in urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-methyl-N-nitrosourea.PMID 1682063Read ↗

Neu is not involved in N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide- induced bladder carcinoma or 2-amino-4-(5-nitro-2-furyl)thiazole transformation of rat bladder epithelial cells.Semantic proximity Read ↗

Infrequent transforming mutations in the transmembrane domain of the neu oncogene in spontaneous rat schwannomas.Semantic proximity Read ↗

Direct sequencing analysis of transmembrane region of human Neu gene by polymerase chain reaction.Semantic proximity Read ↗

Activating missense mutations in Ha-ras-1 genes in a malignant subset of bladder lesions induced by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-[4-(5-nitro-2-furanyl)-2-thiazolyl]formamide.Semantic proximity Read ↗

neu mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats.Semantic proximity Read ↗

neu proto-oncogene mutation is specific for the neurofibromas in a N-nitroso-N-ethylurea-induced hamster neurofibromatosis model but not for hamster melanomas and human Schwann cell tumors.Semantic proximity Read ↗

Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage.Semantic proximity Read ↗

Point mutation in codons 12 and 61 of the Ha-ras gene in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.Semantic proximity Read ↗

H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts.Semantic proximity Read ↗

p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.Semantic proximity Read ↗

Variant mutational activation of the K-ras oncogene in renal mesenchymal tumors induced in newborn F344 rats by methyl(methoxymethyl)nitrosamine.Semantic proximity Read ↗

Ki-ras mutations in spontaneous and chemically induced renal tumors of the rat.Semantic proximity Read ↗

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