Article
neu proto-oncogene mutation is specific for the neurofibromas in a N-nitroso-N-ethylurea-induced hamster neurofibromatosis model but not for hamster melanomas and human Schwann cell tumors.
Cancer research - 15 Feb 1994
Nakamura T, Ushijima T, Ishizaka Y, Nagao M, Nemoto T, Hara M, Ishikawa T
Abstract excerpt
Point mutations of the transmembrane domain coding region of the neu proto-oncogene in N-nitroso-N-ethylurea-induced hamster neurofibromas were found at high frequency (93%; 14 of 15). They involved codons 659 as well as 658, the latter not having been reported previously in rat tumors. The mutat...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cricetinae
- ErbB Receptors
- Ethylnitrosourea
- Guinea Pigs
- Humans
- Melanoma
- Mesocricetus
- Molecular Sequence Data
- Mutation
- Neurofibroma
- Polymerase Chain Reaction
- Proto-Oncogene Mas