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Article

Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage.

Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1991

Nikitin AYu, Ballering L A, Lyons J, Rajewsky M F

Abstract excerpt

The development of malignant tumors of the peripheral nervous system (schwannomas) within a defined intracranial section of the rat trigeminal nerve ("trigeminal box") was used as a model to identify genetic alterations typically associated with the process of cell-lineage-specific oncogenesis induced by exposure to N-ethyl-N-nitrosourea on postnatal day 1. All 47 trigeminal schwannomas (and 12 extracranial...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 1682925
DOI: 10.1073/pnas.88.22.9939
PMCID: PMC52842

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage.PMID 1682925Read ↗

neu mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats.Semantic proximity Read ↗

Suppression of ethylnitrosourea-induced schwannoma development involves elimination of neu/erbB-2 mutant premalignant cells in the resistant BDIV rat strain.Semantic proximity Read ↗

Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells.Semantic proximity Read ↗

Ethylnitrosourea-induced development of malignant schwannomas in the rat: two distinct loci on chromosome of 10 involved in tumor susceptibility and oncogenesis.Semantic proximity Read ↗

Braf Mutations Initiate the Development of Rat Gliomas Induced by Postnatal Exposure to N-Ethyl-N-Nitrosourea.Semantic proximity Read ↗

Infrequent transforming mutations in the transmembrane domain of the neu oncogene in spontaneous rat schwannomas.Semantic proximity Read ↗

Chemically induced rat Schwann cell neoplasia as a model for early-stage human peripheral nerve sheath tumors: phenotypic characteristics and dysregulated gene expression.Semantic proximity Read ↗

Loss of heterozygosity in malignant rat schwannomas chemically induced in hybrids of inbred rat strains with differential tumor susceptibility.Semantic proximity Read ↗

neu mutation in schwannomas induced transplacentally in Syrian golden hamsters by N-nitrosoethylurea: high incidence but low allelic representation.Semantic proximity Read ↗

Rat model of the human "Triton" tumor: direct genetic evidence for the myogenic differentiation capacity of schwannoma cells using the mutant neu gene as a cell lineage marker.Semantic proximity Read ↗

Gender-specific polygenic control of ethylnitrosourea-induced oncogenesis in the rat peripheral nervous system.Semantic proximity Read ↗

Overexpression of activated neu/erbB2 initiates immortalization and malignant transformation of immature Schwann cells in vitro.Semantic proximity Read ↗

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