Article
Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1991
Nikitin AYu, Ballering L A, Lyons J, Rajewsky M F
Abstract excerpt
The development of malignant tumors of the peripheral nervous system (schwannomas) within a defined intracranial section of the rat trigeminal nerve ("trigeminal box") was used as a model to identify genetic alterations typically associated with the process of cell-lineage-specific oncogenesis in...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line
- Cell Transformation, Neoplastic
- DNA, Neoplasm
- Ethylnitrosourea
- Molecular Sequence Data
- Mutagenesis
- Neurilemmoma
- Polymorphism, Restriction Fragment Length
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogenes
- Rats
- Rats, Inbred Strains
- Receptor, ErbB-2
- Schwann Cells