neu mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats.

doi:10.1016/0304-3835(93)90073-i

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Article

neu mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats.

Cancer letters - 15 Jun 1993

Ohgaki H, Vogeley K T, Kleihues P, Wechsler W

Abstract excerpt

The mutational activation of the neu proto-oncogene was analyzed in schwannomas of the peripheral nervous system transplacentally induced by N-ethyl-N-nitrosourea (ENU) in rats. All nine primary schwannomas investigated contained a T-->A transversion mutation at nucleotide 2012 of the neu gene, l...

Topics

Alleles
Animals
Base Sequence
Ethylnitrosourea
Female
Gene Deletion
Molecular Sequence Data
Neurilemmoma
Point Mutation
Polymerase Chain Reaction
Proto-Oncogene Mas
Proto-Oncogenes
Rats
Rats, Inbred BN
Rats, Inbred F344
Sequence Analysis, DNA

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