Article
Neu is not involved in N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide- induced bladder carcinoma or 2-amino-4-(5-nitro-2-furyl)thiazole transformation of rat bladder epithelial cells.
Cancer letters - 29 Aug 1994
Mann A M, Asamoto M, Masui T, Macatee T, Eklund S H, Cohen S M
Abstract excerpt
Enhanced c-erbB-2/neu expression has been linked with a poor prognosis in human bladder cancer. Previous reports have shown that a point mutation at nucleotide T2012 in the coding region of the transmembrane domain of the rat gene is sufficient to confer transformation potential on this gene. We...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Carcinoma, Transitional Cell
- Cell Transformation, Neoplastic
- Cells, Cultured
- Epithelium
- ErbB Receptors
- FANFT
- Gene Expression
- Immunohistochemistry
- Mice
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins
- Rats
- Rats, Inbred F344
- Receptor, ErbB-2