Article
Point mutation in codons 12 and 61 of the Ha-ras gene in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Molecular carcinogenesis - 1 Jan 1990
Masui T, Mann A M, Garland E M, Okamura T, Johansson P L, Cohen S M
Abstract excerpt
Male F344 rats were fed N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) for up to 4 wk, then were given the basal diets (Prolab 3200 or AIN-76A) with or without 5% sodium saccharin for up to 100 wk. Eleven transitional cell carcinomas (TCCs), one undifferentiated carcinoma, and two sarcomas...
Topics
- Animals
- Base Sequence
- Blotting, Western
- Codon
- DNA
- FANFT
- Genes, ras
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Rats
- Rats, Inbred F344
- Urinary Bladder Neoplasms