Article
Infrequent transforming mutations in the transmembrane domain of the neu oncogene in spontaneous rat schwannomas.
Molecular carcinogenesis - 1 Apr 1994
Perantoni A O, Turusov V S, Buzard G S, Rice J M
Abstract excerpt
Ethylnitrosourea (ENU) given transplacentally to rats induces schwannomas of the cranial, spinal, and peripheral nerves, with a high frequency of mutations in the neu proto-oncogene. To establish the requirement for such mutations in tumorigenesis of the Schwann cell, spontaneous schwannomas from...
Topics
- Animals
- Base Sequence
- DNA Primers
- ErbB Receptors
- Female
- Genes, ras
- Male
- Molecular Sequence Data
- Mutation
- Neurilemmoma
- Oncogenes
- Proto-Oncogene Proteins
- Rats
- Receptor, ErbB-2
- Sarcoma, Experimental