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Article

Infrequent transforming mutations in the transmembrane domain of the neu oncogene in spontaneous rat schwannomas.

Molecular carcinogenesis - 1 Apr 1994

Perantoni A O, Turusov V S, Buzard G S, Rice J M

Abstract excerpt

Ethylnitrosourea (ENU) given transplacentally to rats induces schwannomas of the cranial, spinal, and peripheral nerves, with a high frequency of mutations in the neu proto-oncogene. To establish the requirement for such mutations in tumorigenesis of the Schwann cell, spontaneous schwannomas from BD-VI rats were evaluated for transforming mutations in the transmembrane domain of the protein encoded by the neu...

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PMID: 7908527
DOI: 10.1002/mc.2940090407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Infrequent transforming mutations in the transmembrane domain of the neu oncogene in spontaneous rat schwannomas.PMID 7908527Read ↗

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Braf Mutations Initiate the Development of Rat Gliomas Induced by Postnatal Exposure to N-Ethyl-N-Nitrosourea.Semantic proximity Read ↗

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Loss of heterozygosity in malignant rat schwannomas chemically induced in hybrids of inbred rat strains with differential tumor susceptibility.Semantic proximity Read ↗

Ethylnitrosourea-induced development of malignant schwannomas in the rat: two distinct loci on chromosome of 10 involved in tumor susceptibility and oncogenesis.Semantic proximity Read ↗

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Point Mutation of neu Oncogene in Animal Peripheral Nerve Sheath TumorsSemantic proximity Read ↗

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