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Article

Direct sequencing analysis of transmembrane region of human Neu gene by polymerase chain reaction.

Molecular carcinogenesis - 1 Jan 1990

Saya H, Ara S, Lee P S, Ro J, Hung M C

Abstract excerpt

The neu gene in rat neuro/glioblastoma was found to be activated by a single point mutation in the DNA sequence encoding the transmembrane region of the neu-encoded p185 protein. The human homologue of the rat neu gene, termed c-erbB-2 or HER-2, can also be activated in vitro by a similar mutation in the corresponding region. Although the human neu gene was shown to be amplified/overexpressed in a large portion...

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PMID: 2206283
DOI: 10.1002/mc.2940030406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Direct sequencing analysis of transmembrane region of human Neu gene by polymerase chain reaction.PMID 2206283Read ↗

Direct DNA sequencing of the rat neu oncogene transmembrane domain reveals no mutation in urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-methyl-N-nitrosourea.Semantic proximity Read ↗

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Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.Semantic proximity Read ↗

Oncogenic activating mutations in the neu/erbB-2 oncogene are involved in the induction of mammary tumors.Semantic proximity Read ↗

Point Mutation of neu Oncogene in Animal Peripheral Nerve Sheath TumorsSemantic proximity Read ↗

Mutations in transmembrane domain of c-erbB-2 gene in human malignant tumours of the central nervous system.Semantic proximity Read ↗

Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer.Semantic proximity Read ↗

neu proto-oncogene mutation is specific for the neurofibromas in a N-nitroso-N-ethylurea-induced hamster neurofibromatosis model but not for hamster melanomas and human Schwann cell tumors.Semantic proximity Read ↗

Infrequent transforming mutations in the transmembrane domain of the neu oncogene in spontaneous rat schwannomas.Semantic proximity Read ↗

neu mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats.Semantic proximity Read ↗

Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies.Semantic proximity Read ↗

Point mutation of the neu gene in rat neural tumor RT4-AC cells: suppression of tumorigenicity by s-Myc.Semantic proximity Read ↗

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