Article
Direct sequencing analysis of transmembrane region of human Neu gene by polymerase chain reaction.
Molecular carcinogenesis - 1 Jan 1990
Saya H, Ara S, Lee P S, Ro J, Hung M C
Abstract excerpt
The neu gene in rat neuro/glioblastoma was found to be activated by a single point mutation in the DNA sequence encoding the transmembrane region of the neu-encoded p185 protein. The human homologue of the rat neu gene, termed c-erbB-2 or HER-2, can also be activated in vitro by a similar mutatio...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Membrane
- Chromosome Mapping
- DNA
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasms
- Polymerase Chain Reaction
- Proto-Oncogenes
- Tumor Cells, Cultured