H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts.

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Article

H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts.

Cancer research - 1 Jul 1991

Masui T, Mann A M, Macatee T L, Okamura T, Garland E M, Fujii H, Pelling J C, Cohen S M

Abstract excerpt

Male F344 rats were fed 0.2% N-[4-(5-nitro-2-furyl)-2-thiazoly]formamide for 6 weeks and then fed 3% or 5% sodium saccharin, 5% sodium ascorbate, 3.12% calcium saccharin, 1.34% sodium chloride, 5.2% calcium saccharin plus 1.34% sodium chloride, or basal diet alone for 72 weeks. Protein and DNA were extracted from 89 bladder tumors [87 transitional cell carcinomas (TCC), 1 papilloma, and 1 sarcoma] from 86 rats...

Topics

Animals
Ascorbic Acid
Base Sequence
Blotting, Western
Carcinogens
Carcinoma
Carcinoma, Transitional Cell
DNA, Neoplasm
FANFT
Genes, ras
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Proto-Oncogene Proteins p21(ras)

Rats

Rats, Inbred F344

Saccharin

Urinary Bladder Neoplasms

Source

Open in PubMed

Identifiers

PMID: 2054786

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2054786-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts.PMID 2054786Read ↗

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