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Article

PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2010

Baba Yoshifumi, Nosho Katsuhiko, Shima Kaori, Goessling Wolfram, Chan Andrew T, Ng Kimmie, Chan Jennifer A, Giovannucci Edward L, Fuchs Charles S, Ogino Shuji

Abstract excerpt

BACKGROUND: Prostaglandin-endoperoxide synthase 2 (PTGS2, the HUGO Gene Nomenclature Committee-approved official symbol for cycloxygenase-2, COX-2) and its enzymatic product prostaglandin E2 have critical roles in inflammation and carcinogenesis through the G protein-coupled receptor PTGER2 (EP2)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20200425
DOI: 10.1158/1055-9965.EPI-09-1154
PMCID: PMC2837535

Genes

PTGER2
PTGS2
CTNNB1
BRAF
CRABP1
IGF2
IMPACT
KRAS
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20200425-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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