Biological significance of the CpG island methylator phenotype.

doi:10.1016/j.bbrc.2014.07.007

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Article

Biological significance of the CpG island methylator phenotype.

Biochemical and biophysical research communications - 5 Dec 2014

Suzuki Hiromu, Yamamoto Eiichiro, Maruyama Reo, Niinuma Takeshi, Kai Masahiro

Abstract excerpt

Cancers exhibiting the CpG island methylator phenotype (CIMP) are found among a wide variety of human malignancies and represent a subclass of tumors showing concurrent hypermethylation of multiple CpG islands. These CIMP-positive tumors often exhibit characteristic molecular and clinicopathological features, suggesting CIMP represents a distinct carcinogenic pathway. However, marker genes to define CIMP have...

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PMID: 25016183
DOI: 10.1016/j.bbrc.2014.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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