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Article

Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4.

Annals of the New York Academy of Sciences - 1 May 2006

Candore Giuseppina, Aquino Alessandra, Balistreri Carmela Rita, Bulati Matteo, Di Carlo Daniele, Grimaldi Maria Paola, Listì Florinda, Orlando Valentina, Vasto Sonya, Caruso Marco, Colonna-Romano Giuseppina, Lio Domenico, Caruso Calogero

Abstract excerpt

The total burden of infection at various sites may affect the progression of atherosclerosis, the risk being modulated by host genotype. The role of lipopolysaccaride receptor TLR4 is paradigmatic. It initiates the innate immune response against gram-negative bacteria; and TLR4 polymorphisms, as ASP299GLY, suggested to attenuate receptor signaling, have been described. We demonstrated that TLR4 ASP299GLY...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16803999
DOI: 10.1196/annals.1354.037

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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