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Article

Role of TLR4 polymorphisms in inflammatory responses: implications for unsuccessful aging.

Annals of the New York Academy of Sciences - 1 Nov 2007

Balistreri Carmela Rita, Candore Giuseppina, Listì Florinda, Fazio Teresa, Gangi Simona, Incalcaterra Egle, Caruso Marco, Vecchi Maurizio Li, Lio Domenico, Caruso Calogero

Abstract excerpt

The total burden of infection at various sites may affect the progression of atherosclerosis and Alzheimer's disease (AD), the risk being modulated by host genotype. The role of lipopolysaccharide (LPS) receptor TLR4 is paradigmatic. It initiates the innate immune response against gram-negative bacteria, and TLR4 single nucleotide polymorphisms (SNPs), such as +896A/G, known to attenuate receptor signaling, have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18056968
DOI: 10.1196/annals.1404.003

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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