Article
Genetics of inflammation in age-related atherosclerosis: its relevance to pharmacogenomics.
Annals of the New York Academy of Sciences - 1 Apr 2007
Grimaldi Maria Paola, Vasto Sonya, Balistreri Carmela Rita, di Carlo Daniele, Caruso Marco, Incalcaterra Egle, Lio Domenico, Caruso Calogero, Candore Giuseppina
Abstract excerpt
In response to tissue injury elicited by trauma or infection, the inflammatory response, as a complex network of molecular and cellular interactions, sets an answer directed to facilitate a return to physiological homeostasis and tissue repair. The role of the genetic background and the subsequent predisposition toward the extent of the inflammatory response is determined by gene variability encoding endogenous...
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