Article
TLR2 and age-related diseases: potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction.
Rejuvenation research - 1 Apr 2008
Balistreri Carmela Rita, Candore Guiseppina, Mirabile Monica, Lio Domenico, Caimi Gregorio, Incalcaterra Egle, Caruso Marco, Hoffmann Enrico, Caruso Calogero
Abstract excerpt
Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human population. Proinflammatory genotype may be beneficial in early life but not in old people. With...
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