Article
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease.
The Lancet. Infectious diseases - 1 Mar 2005
Schröder Nicolas W J, Schumann Ralf R
Abstract excerpt
Toll-like receptors (TLRs) play an important part in the innate immune recognition of invading microorganisms, initiating sufficient immune responses. Growing amounts of data suggest that the ability of certain individuals to respond properly to TLR ligands may be impaired by single nucleotide polymorphisms (SNPs) within TLR genes, resulting in an altered susceptibility to, or course of, infectious or...
Topics
- Case-Control Studies
- Communicable Diseases
- Genetic Variation
- Humans
- Membrane Glycoproteins
- Polymorphism, Single Nucleotide
- Receptors, Cell Surface
- Toll-Like Receptor 2
- Toll-Like Receptor 4
- Toll-Like Receptors