Article
LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: biological effects of +896A/G TLR4 polymorphism in a Sicilian population of healthy subjects.
Mechanisms of ageing and development - 1 Mar 2011
Balistreri Carmela Rita, Caruso Calogero, Listì Florinda, Colonna-Romano Giuseppina, Lio Domenico, Candore Giuseppina
Abstract excerpt
Toll-like receptors (TLRs) are the principal mediators of rapid microbial recognition: the lipopolysaccharide (LPS) receptor TLR4 seems to have a paradigmatic role. Single nucleotide polymorphisms (SNPs) in the TLR4 gene, such as +896A/G, known to attenuate receptor signaling, have been described. The +896A/G SNP is significantly less frequent in patients with myocardial infarction, Alzheimer's disease or...
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