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Article

TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases.

Journal of clinical immunology - 1 Jul 2009

Balistreri Carmela Rita, Colonna-Romano Giuseppina, Lio Domenico, Candore Giuseppina, Caruso Calogero

Abstract excerpt

INTRODUCTION: Innate immunity provides a first line of host defense against infection by recognizing and killing microbes while simultaneously activating an instructive immune response. Toll-like receptors (TLRs) are principal mediators of rapid microbial recognition and function mainly by detection of pathogen-associated molecular patterns that do not exist in the host. Recognition of their ligands leads to a...

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Source

Identifiers

PMID: 19459036
DOI: 10.1007/s10875-009-9297-5

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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