Article
Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population.
Annals of the New York Academy of Sciences - 1 May 2006
Candore Giuseppina, Balistreri Carmela Rita, Grimaldi Maria Paola, Listì Florinda, Vasto Sonya, Caruso Marco, Caimi Gregorio, Hoffmann Enrico, Colonna-Romano Giuseppina, Lio Domenico, Paolisso Giuseppe, Franceschi Claudio, Caruso Calogero
Abstract excerpt
The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm...
Topics
- Acute Disease
- Aged, 80 and over
- Alleles
- Cytoskeletal Proteins
- Genetic Predisposition to Disease
- Humans
- Inflammation
- Longevity
- Myocardial Infarction
- Pyrin
- Receptors, CCR5
- Sicily