Article
Requirement of reversible caldesmon phosphorylation at P21-activated kinase-responsive sites for lamellipodia extensions during cell migration.
Cell motility and the cytoskeleton - 1 Sept 2006
Eppinga Robbin D, Li Yan, Lin Jenny L-C, Mak Alan S, Lin Jim J-C
Abstract excerpt
Caldesmon is believed to be one of the key regulators for actin dynamics and thereby cell polarity, membrane extension, and cell motility. We have shown previously that stress fiber formation and cell movement are severely impaired in the cells expressing human fibroblast caldesmon fragment defective in Ca2+/CaM binding sites. Both Ser458 and Ser489, adjacent to the Ca2+/CaM-binding sites, are phosphorylated by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.